In Slico Study of Green Tea (Camellia Sinensis) Extract Epigallocatechine Gallate as an Inhibitor of Alzheimer's and Myositis Using Beta Secretase 1
Kata Kunci:
Epigallocatechine Gallate, Alzheimer, Myositis, Beta Secretase 1, In SilicoAbstrak
This research entitled "In Silico Study of Epigallocatechine Gallate Green Tea Extract (Camellia Sinensis) as an Alzheimer and Myositis Inhibitor Using Beta Secretase 1" examines the effectiveness of epigallocatechine gallate (EGCG) as an inhibitor of Alzheimer and Myositis. The research method used is in silico with PyMOL and Pyrex software for molecular simulation and Protein Plus for protein interaction analysis. Analysis of binding affinity calculations showed values of -8.1, -8.1, and -8.0 with RMSD values of 0, 1.443, and 1.767. This study produced evidence that there is an interaction between EGCG and Beta Secretase 1 which illustrates the potential of EGCG as an inhibitor of Alzheimer's and Myositis. Lepinski Rule analysis showed that EGCG has a molecular weight of 448, 8 hydrogen bond donors, 11 hydrogen bond acceptors, a log P value of -3.316 and a molar reactivity of 93.0303. These conclusions indicate that EGCG meets the criteria of Lepinski's rule as a good drug candidate, and therefore shows potential as a therapeutic agent in the treatment of Alzheimer's and Myositis.
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