Computational Screening of Toxicity, Drug-like Molecule, and Bioactivity from Green Tea Phytochemical as Antiviral Candidate
Kata Kunci:
Antiviral, Computational Screening, Bioactivity, Green Tea, PhytochemicalAbstrak
Viruses are obligate intracellular parasites because they can infect cells and hijack the gene expression process in host cells for the replication of viral genetic material. The mechanism of the viral life cycle is generally divided into three stages such as viral entry, genome replication, budding, and release. Several viruses can inhibit interferon signaling through the JAK/STAT pathway such as human cytomegalovirus (HCMV), HIV-1, murine hepatitis virus (MHV), severe acute respiratory syndrome coronavirus (SARS-CoV-2), & vaccinia virus (VACV). Antiviral drugs can be developed by studying how viruses evade the immune response, several drugs have been discovered but most of them are synthetic compounds that produce the use effect. Screening of drug candidate compounds can be carried out on a specific natural ingredient such as green tea used in this study. Scientific evidence of compounds from green tea as an antiviral agent is very little, this study is important because it is to screen the potential of compounds from green tea as an antiviral agent through computational approach. Green Tea phytochemical compounds are predicted to be antiviral based on in silico analysis. Antiviral candidate are EGCG, ECG, EGC, EC, & Catechin, they are drug-like molecules and have positive probabilities as antiviral agents.
Referensi
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